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M U H I M B I L I   M E D I C A L   R E S E A R C H   C E N T R E

National Institute for Medical Research

Muhimbili Medical Research Centre



Kilosa Research Station

Kilosa research Station originates from the Rectal Artesunate Clinical (RECTOCAP) Trial which was carried out in Kilosa District from 1999. The Station is within the Kilosa District Hospital, located in at about 100 km from Morogoro in central Tanzania. The Station utilizes hospital buildings renovated using funds obtained from the Swedish Embassy in Tanzania. In 2000, permission was granted by the district health authorities to re-construct three permanent offices to constitute a research base for a clinical trial. In 2006, the Kilosa clinical trial offices were formally absorbed into the structure of the National Institute for Medical Research (NIMR) of Tanzania as the Kilosa Station under NIMR’s Muhimbili Centre.

Kilosa Research Station has provided the basis for other research and research capacity. Some activities and studies undertaken at the Kilosa Station were:

  • 01. Health systems barriers to malaria interventions: exploring access, treatment, and referral in Tanzania.
  • 02. Management of severe childhood malaria in the community in Kilosa district, Tanzania: collaboration with traditional healers
  • 03. Measuring prevalence of anemia among children with severe falciparum malaria - Methodological considerations from the Rectal artesunate study
  • 04. Use and acceptability of rectal medication in rural settings of Tanzania
  • 05. Use and availability of antimalarial drugs in the urban and rural settings of Tanzania
  • 06. Influence of healthcare infrastructure on child mortality in Morogoro Rural District, Tanzania
  • 07. Real-life deployment of Rectal Artesunate as an Initial Treatment in the Management of malaria non per os children in a rural community, Tanzania. A study that looked into mechanisms of delivering rectal Artesunate in the rural community of Mtwara.
  • 08. A multi-country hospital-based clinical trial: Efficacy and safety of rectal artesunate in paediatric patients a randomized controlled study: UNICEF/UNDP/World Bank/ WHO Special Program for Research and Training in Tropical Diseases (TDR) funded.
  • 09. A multi-country hospital-based clinical trial: Efficacy, safety and population-pharmacokinetics of artesunate-mefloquine combination for the treatment of uncomplicated falciparum malaria in African children versus artemether-lumefantrine
  • 10. Factors influencing access and speed of access to health care services for children with severe febrile illness in rural Tanzania.
  • 11. Mapping of households that had under-fives between 2001 and 2006 in villages in Kilosa and Handeni that were involved in rectal artesunate.
  • 12. Kilosa participated in the design and conduction of the Neurocognitive Assessment Battery for low- and middle-income developing countries including Tanzania. This has later been recognized as the “East-African Neurocognitive Assessment Battery”